| R | Date | Home | Score | Away | HT | Crowd | >2.5 | HT | FT | TV | Time | Rating | Ref. | Location | |
| 1 | 06.08.2006 | Derby County | 2 - 2 | Southampton | 1-0 | 21'939 | Yes | 1 | X | 16:00 | 0 | 0 | |||
| 2 | 09.08.2006 | Southampton | 2 - 0 | Coventry City | 0-0 | 21'088 | No | X | 1 | 19:45 | 0 | 0 | |||
| 3 | 12.08.2006 | Southampton | 0 - 0 | West Brom | 0-0 | 24'233 | No | X | X | 15:00 | 0 | 0 | |||
| 4 | 19.08.2006 | Barnsley | 2 - 2 | Southampton | 1-0 | 11'306 | Yes | 1 | X | 15:00 | 0 | 0 | |||
| 5 | 26.08.2006 | Southampton | 1 - 1 | Preston | 1-0 | 20'712 | No | 1 | X | 15:00 | 0 | 0 | |||
| 6 | 09.09.2006 | Ipswich Town | 2 - 1 | Southampton | 0-1 | 21'422 | Yes | 2 | 1 | 15:00 | 0 | 0 | |||
| 7 | 12.09.2006 | Crystal Pal. | 0 - 2 | Southampton | 0-1 | 17'084 | No | 2 | 2 | 20:00 | 0 | 0 | |||
| 8 | 16.09.2006 | Southampton | 1 - 0 | Plymouth Argyle | 0-0 | 22'514 | No | X | 1 | 15:00 | 0 | 0 | |||
| 9 | 23.09.2006 | Burnley | 2 - 3 | Southampton | 2-1 | 13'051 | Yes | 1 | 2 | 15:00 | 0 | 0 | |||
| 10 | 30.09.2006 | Southampton | 1 - 2 | QPR | 1-2 | 25'185 | Yes | 2 | 2 | 15:00 | 0 | 0 | |||
| 11 | 14.10.2006 | Leicester City | 3 - 2 | Southampton | 1-1 | 21'347 | Yes | X | 1 | 15:00 | 0 | 0 | |||
| 12 | 17.10.2006 | Cardiff City | 1 - 0 | Southampton | 0-0 | 19'345 | No | X | 1 | 19:45 | 0 | 0 | |||
| 13 | 21.10.2006 | Southampton | 1 - 0 | Stoke City | 0-0 | 20'531 | No | X | 1 | 15:00 | 0 | 0 | |||
| 14 | 28.10.2006 | Colchester Utd | 2 - 0 | Southampton | 1-0 | 5'893 | No | 1 | 1 | 15:00 | 0 | 0 | |||
| 15 | 01.11.2006 | Southampton | 2 - 0 | Wolves | 1-0 | 18'979 | No | 1 | 1 | 19:45 | 0 | 0 | |||
| 16 | 04.11.2006 | Southampton | 0 - 0 | Hull City | 0-0 | 20'560 | No | X | X | 15:00 | 0 | 0 | |||
| 17 | 11.11.2006 | Sunderland | 1 - 1 | Southampton | 0-0 | 25'667 | No | X | X | 15:00 | 0 | 0 | |||
| 18 | 18.11.2006 | Leeds United | 0 - 3 | Southampton | 0-1 | 19'647 | Yes | 2 | 2 | 15:00 | 0 | 0 | |||
| 19 | 25.11.2006 | Southampton | 2 - 1 | Luton Town | 2-0 | 20'482 | Yes | 1 | 1 | 15:00 | 0 | 0 | |||
| 20 | 29.11.2006 | Southampton | 4 - 3 | Birmingham City | 3-0 | 21'889 | Yes | 1 | 1 | 19:45 | 0 | 0 | |||
| 21 | 02.12.2006 | Hull City | 2 - 4 | Southampton | 2-2 | 15'697 | Yes | X | 2 | 15:00 | 0 | 0 | |||
| 22 | 09.12.2006 | Southend Utd | 2 - 1 | Southampton | 1-0 | 10'867 | Yes | 1 | 1 | 15:00 | 0 | 0 | |||
| 23 | 16.12.2006 | Southampton | 2 - 1 | Norwich City | 1-1 | 25'919 | Yes | X | 1 | 15:00 | 0 | 0 | |||
| 24 | 23.12.2006 | Sheffield Wed | 3 - 3 | Southampton | 1-2 | 23'739 | Yes | 2 | X | 15:00 | 0 | 0 | |||
| 25 | 26.12.2006 | Southampton | 1 - 1 | Crystal Pal. | 0-0 | 30'548 | No | X | X | 12:00 | 0 | 0 | |||
| 26 | 30.12.2006 | Southampton | 2 - 0 | Leicester City | 0-0 | No | X | 1 | 15:00 | 0 | 0 | ||||
| 27 | 01.01.2007 | Plymouth Argyle | 1 - 1 | Southampton | 0-0 | No | X | X | 15:00 | 0 | 0 | ||||
| 28 | 13.01.2007 | Southampton | 0 - 0 | Burnley | 0-0 | No | X | X | 15:00 | 0 | 0 | ||||
| 29 | 20.01.2007 | QPR | 0 - 2 | Southampton | 0-0 | No | X | 2 | 15:00 | 0 | 0 | ||||
| 30 | 31.01.2007 | Southampton | 2 - 1 | Sheffield Wed | 0-0 | Yes | X | 1 | 19:45 | 0 | 0 | ||||
| 31 | 03.02.2007 | Southampton | 0 - 1 | Derby County | 0-0 | No | X | 2 | 15:00 | 0 | 0 | ||||
| 32 | 10.02.2007 | West Brom | 1 - 1 | Southampton | 0-0 | No | X | X | 15:00 | 0 | 0 | ||||
| 33 | 17.02.2007 | Southampton | 5 - 2 | Barnsley | 0-0 | Yes | X | 1 | 15:00 | 0 | 0 | ||||
| 34 | 20.02.2007 | Coventry City | 2 - 1 | Southampton | 0-0 | Yes | X | 1 | 19:45 | 0 | 0 | ||||
| 35 | 24.02.2007 | Southampton | 1 - 0 | Ipswich Town | 0-0 | No | X | 1 | 15:00 | 0 | 0 | ||||
| 36 | 05.03.2007 | Preston | - | Southampton | 15:00 | ||||||||||
| 37 | 10.03.2007 | Stoke City | - | Southampton | 15:00 | ||||||||||
| 38 | 13.03.2007 | Southampton | - | Cardiff City | 19:45 | ||||||||||
| 39 | 16.03.2007 | Southampton | - | Colchester Utd | 15:00 | ||||||||||
| 40 | 31.03.2007 | Wolves | - | Southampton | 15:00 | ||||||||||
| 41 | 07.04.2007 | Luton Town | - | Southampton | 15:00 | ||||||||||
| 42 | 09.04.2007 | Southampton | - | Sunderland | 15:00 | ||||||||||
| 43 | 14.04.2007 | Birmingham City | - | Southampton | 15:00 | ||||||||||
| 44 | 21.04.2007 | Southampton | - | Leeds United | 15:00 | ||||||||||
| 45 | 28.04.2007 | Norwich City | - | Southampton | 15:00 | ||||||||||
| 46 | 06.05.2007 | Southampton | - | Southend Utd | 15:00 |